Managing Extemporaneous Oral Liquids in Practice

Stability of an alternative extemporaneous captopril fast-dispersing tablet formulation versus an extemporaneous oral liquid formulation.

BACKGROUND Administration of medications to pediatric patients is challenging because many drugs are not commercially available in appropriate dosage formulations and/or strengths. Consequently, these drugs are prepared extemporaneously as oral liquid (OL) formulations using marketed tablets or capsules. In many cases, the stability of these extemporaneous preparations, which may affect their t...

Stability of extemporaneous pediatric oral liquids compounded from tablets and drug substance: case of propranolol and theophylline.

The stability of theophylline (T) and propranolol hydrochloride (P) in extemporaneously compounded oral suspensions (25 mg/mL or 50 mg/mL for T and 2 mg/mL or 5 mg/mL for P) were studied. Suspension with P and T were prepared with bulk substance or tablets using three different suspending vehicles: Ora-Sweet (M1), modified Ora-Sweet (M2) and simple syrup with glycerol and sorbitol (M3). Each su...

Extemporaneous oral liquid medications - A review of stability issues

Liquid dosage forms extemporaneously prepared from commercially available products - considering new evidence on stability.

Although the world's population is ageing and as a result of this an increasing number of patients are experiencing difficulty in swallowing, there remains a lack of commercially available oral liquids for both these older and paediatric patients. This presents a problem to health care professionals, especially the pharmacist in practice, who is often required to provide a solution for these pa...

Modeling Extemporaneous Elaboration

Intelligent problem solving systems must be able to express their results in a coherent and flexible manner. One way this can be done is by eztemporaneous elaboration, the method of language production that underlies more skilled tasks such as explanation. This paper outlines a computational model for extemporaneous elaboration that is implemented in a computer model called Extemper, shows exam...